Kevin R Lynch Selected Research

Sphingosine-1-Phosphate Receptors

1/2020	Mechanism of sphingosine 1-phosphate clearance from blood.
6/2015	Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury.
5/2012	Building a better sphingosine kinase-1 inhibitor.
5/2011	Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
6/2010	Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
4/2009	S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.
10/2008	Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2.
1/2007	Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.
1/2007	Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury.

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Kevin R Lynch Research Topics

Disease

17	Neoplasms (Cancer) 02/2021 - 03/2007
10	Inflammation (Inflammations) 02/2021 - 11/2005
8	Reperfusion Injury 04/2017 - 09/2003
7	Fibrosis (Cirrhosis) 04/2017 - 10/2008
6	Lymphopenia (Lymphocytopenia) 04/2015 - 06/2002
5	Sickle Cell Anemia (Hemoglobin S Disease) 11/2017 - 09/2014
4	Hypoxia (Hypoxemia) 01/2020 - 02/2008
4	Ischemia 01/2018 - 09/2003
4	Acute Kidney Injury (Acute Renal Failure) 11/2016 - 09/2003
4	Neoplasm Metastasis (Metastasis) 01/2015 - 08/2008
3	Multiple Sclerosis 01/2020 - 06/2002
3	Ovarian Neoplasms (Ovarian Cancer) 01/2015 - 10/2003
2	Lung Injury 01/2018 - 06/2015
2	Autoimmune Diseases (Autoimmune Disease) 09/2012 - 06/2002
2	Pathologic Processes 05/2012 - 05/2009
2	Breast Neoplasms (Breast Cancer) 09/2011 - 09/2009
2	Melanoma (Melanoma, Malignant) 09/2009 - 10/2005
2	Wilms Tumor (Wilm's Tumor) 04/2009 - 10/2008
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2008 - 04/2003
1	Chikungunya Fever 01/2022
1	Infections 01/2022
1	Death (Near-Death Experience) 01/2018
1	Acute Lung Injury 01/2018
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2018
1	Ischemic Stroke 01/2018
1	Brain Hypoxia (Cerebral Hypoxia) 01/2018
1	Brain Ischemia (Cerebral Ischemia) 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 12/2016
1	Heart Diseases (Heart Disease) 04/2014
1	Obesity 04/2014
1	Carcinogenesis 09/2011
1	Leukemia 05/2011
1	Diabetic Nephropathies (Diabetic Nephropathy) 05/2011
1	Albuminuria 05/2011
1	Cognitive Dysfunction 05/2010
1	Catalepsy 08/2009
1	Hypothermia 08/2009
1	Vascular System Injuries 08/2008
1	Hyperplasia 08/2008
1	Bradycardia 08/2005
1	Disease Progression 04/2003

Drug/Important Bio-Agent (IBA)

21	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 02/2021 - 06/2002
15	SphingosineIBA 01/2022 - 11/2005
10	Fingolimod Hydrochloride (FTY720)FDA Link 06/2015 - 06/2002
9	sphingosine kinaseIBA 01/2022 - 06/2002
9	Sphingosine-1-Phosphate ReceptorsIBA 01/2020 - 01/2007
8	Phosphotransferases (Kinase)IBA 01/2022 - 11/2005
8	LipidsIBA 05/2016 - 08/2008
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2017 - 09/2003
4	lysophosphatidic acidIBA 01/2015 - 09/2003
3	Protein Isoforms (Isoforms)IBA 02/2021 - 02/2008
3	Messenger RNA (mRNA)IBA 04/2017 - 02/2008
3	Pharmaceutical PreparationsIBA 12/2016 - 03/2007
3	EnzymesIBA 03/2016 - 10/2005
3	Lysophosphatidic Acid ReceptorsIBA 06/2012 - 09/2003
2	Oxygen (Dioxygen)IBA 01/2020 - 01/2018
2	SphingolipidsIBA 01/2018 - 06/2012
2	Proteins (Proteins, Gene)FDA Link 04/2017 - 10/2008
2	Phosphates (Orthophosphate)IBA 01/2015 - 10/2005
2	ProdrugsIBA 05/2012 - 11/2005
2	SEW2871IBA 05/2011 - 06/2010
2	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 09/2009 - 10/2003
1	Neuroprotective AgentsIBA 01/2018
1	NitrogenIBA 01/2018
1	Folic Acid (Vitamin M)FDA LinkGeneric 04/2017
1	Cell Adhesion MoleculesIBA 11/2016
1	rac- ((1R,3S)- 1- amino- 3- (4- octylphenyl)cyclopentyl)methanol hydrochlorideIBA 06/2015
1	LigandsIBA 02/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2015
1	CytokinesIBA 09/2014
1	Amitriptyline (Elavil)FDA LinkGeneric 09/2014
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 09/2014
1	AcidsIBA 09/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2014
1	DiglyceridesIBA 06/2012
1	Glycerol (Glycerine)FDA LinkGeneric 06/2012
1	1- (hydroxymethyl)- 3- (3- octylphenyl)cyclobutaneIBA 09/2011
1	Antineoplastic Agents (Antineoplastics)IBA 09/2011
1	Mitogen-Activated Protein KinasesIBA 06/2010
1	CannabinoidsIBA 08/2009
1	Small Interfering RNA (siRNA)IBA 04/2009
1	Growth InhibitorsIBA 10/2008
1	Connective Tissue Growth FactorIBA 10/2008
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 08/2008
1	PyrophosphatasesIBA 08/2008
1	alkylglycerophosphoethanolamine phosphodiesteraseIBA 08/2008
1	NucleotidesIBA 08/2008
1	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)IBA 03/2007
1	VPC32183IBA 10/2005
1	Immunologic Factors (Immunomodulators)IBA 10/2005
1	phosphoric acid mono- (3- (4- benzyloxyphenyl)- 2- octadec- 9- enoylaminopropyl) esterIBA 09/2003
1	Insulin (Novolin)FDA Link 04/2003

Therapy/Procedure

5	Therapeutics 05/2016 - 08/2005
2	Drug Therapy (Chemotherapy) 01/2018 - 09/2009
2	Intraperitoneal Injections 01/2015 - 08/2008
1	Warm Ischemia 01/2018
1	Lung Transplantation 06/2015
1	Transplantation 05/2010
1	Immunomodulation 08/2008
1	Oral Administration 12/2007